BONEPRINTING - Laser assisted bioimpression

Laser assisted bioimpression for in vivo bone tissue engineering in mice.

(2011- 2015)

About the project:

Tissue engineering can be defined as the set of techniques and methods based on the principles of engineering and of life sciences to develop biological substitutes that can restore, maintain or improve tissue functions. Hence, research in this area is an interdisciplinary field combining knowledge and methods from physics, cell biology, chemical engineering, material science, mathematics.

In this context, we are interested in developing a methodology for biological materials printing by laser. Based on the principle of the method Laser-Induced Forward Transfer (LIFT) method, Laser-Assisted Bioprinting (LAB) was proposed in 2002 by the Naval Research Laboratory (Washington, USA) for the deposition of biomolecules and cells on the surface of biomaterials. This method has the advantage of allowing large degrees of freedom in terms of the nature and the volume of biological elements to be "manipulated", and enjoys the advantages of laser technologies such as lack of contact, spatial resolution and manipulation speed.

ALPhANOV's role:

Validate the methodology for laser assisted biological materials printing, optimize the procedure,  and develop, if necessary, a well-suited laser source.

Partners:

• Université Bordeaux 2
• Inserm
• CIC-IT
• UPMC
• CMCP
• Collège de France

Funding:

CRA, ANR